IDCRC Investigator Profile: Marcela F. Pasetti, PhD
Marcela F. Pasetti, PhD, is an immunologist and professor of pediatrics at the University of Maryland School of Medicine. She also serves as the chief of the Applied Immunology Section at the Center for Vaccine Development.
Dr. Pasetti's research focuses on vaccines and immunology to understand how protective immunity can be induced in animal models and in humans following infection and vaccination, and the mechanisms involved. Her primary areas of interest are pediatric vaccines, mucosal immunity, neonatal and infant immunology, and maternal immunization. She investigates novel vaccine strategies, antigen delivery systems, adjuvants, and immunization regimens for protection against pathogens that affect young children, as well as the influence of maternal immunity in the protection of young infants and their responses to vaccination.
Dr. Pasetti serves as the Endpoint Laboratory principal investigator for the IDCRC PROMISE and Measles study. Read about IDCRC Studies here.
How long have you worked with a VTEU?
I have been with the VTEU for more than two decades. Mike Levine was the UMB principal investigator at that time.
Can you share more about a current IDCRC study you're working on?
Our laboratory conducts immunological assays to support clinical studies. We have completed the qualification of serum and breast milk antibody assays for IDCRC 24-0003 PROMISE and are testing samples. We have also optimized a B memory assay for IDCRC 2025-0003 Measles immunity in the US: a post-elimination era evaluation.
Briefly describe the IDCRC-supported trials you’ve supported.
Of these trials, what has been the most impactful or a highlight of the work?
All of them, but probably MOMI-Vax and now PROMISE, are highlights for me, as I am interested in maternal-infant immunity and pediatric vaccines.
What is a strength or example of the importance of the IDCRC during the pandemic and beyond?
The IDCRC is unique in its capacity to advance clinical research. It supports high-complexity, rigorous clinical trials involving multiple sites. It brings together accomplished investigators of multiple disciplines and institutions.
What do you like to do outside of the VTEU?
I lead other research initiatives related to vaccines and immunity to mucosal pathogens. I enjoy being a mentor — I have a great team. Outside of my work, I enjoy the outdoors, helping in the community, and music (playing piano).